PHAHumectantKeratolyticAnti-inflammatoryAntioxidant

Polyhydroxy Acids

✅ solid choice Tier 2 Evidence

what it does

A family of next-generation exfoliants with larger molecules than AHAs, offering gentler exfoliation and simultaneous hydration. Gluconolactone is the most studied PHA.

dermai take

AHAs for people whose skin cried at glycolic acid. PHAs exfoliate so gently you barely notice — but the results are real and there's zero burning. Solid option for reactive skin that still wants chemical exfoliation benefits.

targets these concerns

Pores Texture

the studies

"Comparison of Efficacy and Willingness to a 5% Gluconolactone-Based Topical Serum and Intense Pulsed Light in Mild Erythema of Rosacea."

Journal of cosmetic dermatology (2025) · Peng Y, Mao M, Huang Z et al.

"Efficacy and safety of a new peeling formulated with a pool of PHAs for the treatment of all skin types, even sensitive."

Journal of cosmetic dermatology (2023) · Gentili G, Perugini P, Bugliaro S et al.

"A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acne."

The Australasian journal of dermatology (1992) · Hunt MJ, Barnetson RS