โ† ingredient library
AHAKeratolyticBrightening

Glycolic Acid

๐Ÿ† hero ingredient Tier 1 Evidence

what it does

The smallest AHA molecule, glycolic acid penetrates deepest for maximum exfoliation, collagen stimulation, and pigmentation correction. The most clinically studied alpha-hydroxy acid.

dermai take

The brute-force exfoliant. Smallest molecule = deepest penetration = most dramatic results. It will make your skin glow or make you peel โ€” entirely depending on whether you respect the percentage. Start low, patch test, don't get reckless.

targets these concerns

don't combine with

Tretinoinmedium

Glycolic acid increases tretinoin absorption and risk of irritation. Use glycolic strictly in AM and tretinoin strictly at night.

๐Ÿ’ก AM: glycolic acid. PM: tretinoin only. Never same session.

Retinolmedium

Both promote cell turnover โ€” layering them risks over-exfoliation, redness, and prolonged sensitivity.

๐Ÿ’ก Alternate nights. Do not layer in the same session.

the studies

"Efficacy and safety of 5% glycolic acid-based Gel essence in the treatment of mild to moderate acne."
Journal of cosmetic dermatology (2022) ยท Chen L, Lu L, Tu S et al.
"Effectiveness of water as the neutralising agent for glycolic acid peels in skin phototypes IV-V."
The Australasian journal of dermatology (2021) ยท Sitohang IBS, Rahmayunita G, Hosfiar VA et al.